Pharmacokinetic and pharmacodynamic parameters of the selective serotonin re-uptake inhibitor (SSRI) citalopram [1-(3-dimethylaminopropyl) -1-(4-fluorophenyl)-5- phtalancarbonitril] were determined in order to find optimal conditions for augmentation of its effect on extracellular serotonin (5-HT) through blockade of 5-HT1A and 5-HT1B
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چکیده
receptor antagonist critically depends on the dose of citalopram. Abstract Pharmacokinetic and pharmacodynamic parameters of the selective serotonin re-uptake inhibitor (SSRI) citalopram
منابع مشابه
Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT1B autoreceptors
Rationale: 5-HT autoreceptors regulate extracellular 5-HT levels and have been suggested to limit the effects of acute treatment with selective serotonin reuptake inhibitors (SSRI). Objectives: The role of terminal 5-HT1B autoreceptors was assessed by comparing the effects of a SSRI on extracellular 5-HT in wildtype and 5-HT1B receptor knockout mice, and by using a 5-HT1B receptor antagonist. S...
متن کاملCelexa Approval
DESCRIPTION Celexa (citalopram HBr) is an orally administered selective serotonin reuptake inhibitor (SSRI) TM with a chemical structure unrelated to that of other SSRI’s or of tricyclic, tetracyclic, or other available antidepressant agents. Citalopram HBr is a racemic bicyclic phthalane derivative designated (±)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitr...
متن کاملCelexa Approval
DESCRIPTION Celexa (citalopram HBr) is an orally administered selective serotonin reuptake inhibitor (SSRI) TM with a chemical structure unrelated to that of other SSRI’s or of tricyclic, tetracyclic, or other available antidepressant agents. Citalopram HBr is a racemic bicyclic phthalane derivative designated (±)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitr...
متن کاملThe effects of selective serotonin reuptake inhibitors on extracellular 5-HT in the hippo- campus of 5-HT1B receptor knockout mice
The effects of two selective serotonin reuptake inhibitors (SSRIs) on 5-hydroxytryptamine (5-HT) in the hippocampus were studied in wildtype and in 5-HT1B receptor knockout (KO) mice using in vivo microdialysis. Basal 5-HT levels were not different between the two genotypes. The functional absence of 5-HT1B receptors was examined in the knockout mice by local infusion of the 5-HT1B receptor ago...
متن کاملShort communication Improved efficacy of f luoxetine in increasing hippocampal 5-hydroxytryptamine outf low in 5-HT1B receptor knock-out mice
To test for the contribution of the 5-HT1B receptor subtype in mediating the effects of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), we used intracerebral in vivo microdialysis in awake, freely moving 5-HT1B receptor knock-out mice. We show that a single systemic administration of fluoxetine (1, 5 or 10 mg/kg, i.p.) increased extracellular serotonin levels [5-HT]ext in the ventr...
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